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Cellosaurus SK-BR-7 (CVCL_5218)

[Text version]

Cell line name SK-BR-7
Synonyms SK-Br-7; SK BR 07; SKBR-7; SKBr7; SKBR7
Accession CVCL_5218
Resource Identification Initiative To cite this cell line use: SK-BR-7 (RRID:CVCL_5218)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Omics: miRNA expression profiling.
Omics: Transcriptome analysis.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Sequence variations Homozygous for CDKN2A deletion (PubMed=19593635).
Heterozygous for KRAS p.Gly12Cys (c.34G>T) (PubMed=19593635).
Heterozygous for NRAS p.Gln61Arg (c.182A>G) (PubMed=19593635).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO10
D2S133820,23
D3S135816
D5S81812
D7S8209,11
D8S117910,11
D13S3178,11
D16S53911,12
D18S5112,13
D19S43315,15.2
D21S1129,31
FGA22,23
TH016,8
TPOX9,11
vWA14,17

Run an STR similarity search on this cell line
Web pages http://www.pawefish.path.cam.ac.uk/BreastCellLineDescriptions/sk-br-7.htm
Publications

PubMed=11044355; DOI=10.1054/bjoc.2000.1458
Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C., Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M., van den Ouweland A., Merajver S.D., Ethier S.P., Schutte M.
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F., Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J., Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M., Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M., Dinjens W.N.M., Ethier S.P., Clevers H., Jochemsen A.G., den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=23601657; DOI=10.1186/bcr3415
Riaz M., van Jaarsveld M.T.M., Hollestelle A., Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J., Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A.C., Foekens J.A., Martens J.W.M.
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33-R33(2013)

Cross-references
Cell line databases/resources DepMap; ACH-002330
Chemistry resources PharmacoDB; SKBR7_1385_2019
Gene expression databases GEO; GSM75171
GEO; GSM217597
GEO; GSM219966
GEO; GSM421885
Other Wikidata; Q54953626
Polymorphism and mutation databases Cosmic; 1046946
Cosmic; 1287927
Cosmic; 1289407
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number19