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Cellosaurus LoVo-92 (CVCL_5237)

Cell line name LoVo-92
Synonyms Lovo-92; Lovo 92; Lovo92
Accession CVCL_5237
Resource Identification Initiative To cite this cell line use: LoVo-92 (RRID:CVCL_5237)
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
APC p.Arg1114Ter (c.3340C>T), p.Met1431fs*42 (c.4289delC) and p.Arg2816Gln (c.8447G>A) (from parent cell line).
KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
SMAD2 p.Ala292Val (c.875C>T) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0399 (LoVo)
CVCL_6A75 (Lovo-143X19)CVCL_6A76 (Lovo-143X3)CVCL_5235 (Lovo-175X2)
CVCL_5236 (Lovo-273X17)CVCL_5238 (LoVo-li)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line

Pocard M., Chevillard S., Villaudy J., Poupon M.-F., Dutrillaux B., Remvikos Y.
Different p53 mutations produce distinct effects on the ability of colon carcinoma cells to become blocked at the G1/S boundary after irradiation.
Oncogene 12:875-882(1996)

PubMed=9989828; DOI=10.1038/sj.onc.1202336
Soulie P., Poupon M.-F., Remvikos Y., Dutrillaux B., Muleris M.
Distinct chromosomal alterations associated with TP53 status of LoVo cells under PALA selective pressure: a parallel with cytogenetic pathways of colorectal cancers.
Oncogene 18:775-781(1999)

PubMed=17339891; DOI=10.1038/sj.bjc.6603639
Giovannetti E., Backus H.H.J., Wouters D., Ferreira C.G., van Houten V.M.M., Brakenhoff R.H., Poupon M.-F., Azzarello A., Pinedo H.M., Peters G.J.
Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
Br. J. Cancer 96:769-775(2007)

PubMed=18600534; DOI=10.1080/15257770802145512
Giovannetti E., Backus H.H.J., Wouters D., Peters G.J.
Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
Nucleosides Nucleotides Nucleic Acids 27:740-745(2008)

Ontologies BTO; BTO:0004146
Gene expression databases GEO; GSM503149
Other Wikidata; Q54902900