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Cellosaurus C75 (CVCL_5248)

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Cell line name C75
Accession CVCL_5248
Resource Identification Initiative To cite this cell line use: C75 (RRID:CVCL_5248)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Colon; sigmoid.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Unspecified (PubMed=16418264; DepMap).
HLA typing Source: PubMed=8464898
Class I
HLA-AA*01,11
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): DepMap; ECACC; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO12
D3S135815,16
D5S8188,12 (DepMap; PubMed=25926053)
12 (ECACC)
D7S8209,11
D8S117912,13
D13S31710,13
D16S5398,11
D18S5112,14
D21S1127,31 (DepMap)
31 (PubMed=25926053)
FGA23
Penta D12,15
Penta E12
TH018,9.3
TPOX10
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8464898; DOI=10.1073/pnas.90.7.2842
Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., Bodmer W.F.
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=10737795; DOI=10.1073/pnas.97.7.3352
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105
Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=23272949; DOI=10.1186/1755-8794-5-66
Schlicker A., Beran G., Chresta C.M., McWalter G., Pritchard A., Weston S., Runswick S., Davenport S., Heathcote K., Castro D.A., Orphanides G., French T., Wessels L.F.A.
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)

Cross-references
Cell line collections ECACC; 12022907
Ximbio; 151758
Cell line databases/resources Cell_Model_Passport; SIDM01533
ColonAtlas; C75
DepMap; ACH-001458
Encyclopedic resources Wikidata; Q54808240
Gene expression databases GEO; GSM1374422
GEO; GSM1448201
Polymorphism and mutation databases Cosmic; 986008
Cosmic; 995387
Cosmic; 1043801
Cosmic; 1312293
Cosmic; 2760095
IARC_TP53; 21734
Proteomic databases PRIDE; PXD005354
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number23