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Cellosaurus MaTu (CVCL_5328)

Cell line name MaTu
Synonyms MATU; BrCL20
Accession CVCL_5328
Resource Identification Initiative To cite this cell line use: MaTu (RRID:CVCL_5328)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=10508494; PubMed=20143388). Originally thought to originate from a breast carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00142.
Microsatellite instability: Stable (MSS) (PubMed=15677628).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Sequence variations Heterozygous for EP300 Ex20-21del (c.4790del138) and c.6260+2T>A (PubMed=10700188).
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_5329 (MaTu/Ham)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=212193
Engel L.W., Young N.A.
Human breast carcinoma cells in continuous culture: a review.
Cancer Res. 38:4327-4339(1978)

PubMed=9150904; DOI=10.1023/A:1005756632293
Hambly R.J., Double J.A., Thompson M.J., Bibby M.C.
Establishment and characterisation of new cell lines from human breast tumours initially established as tumour xenografts in NMRI nude mice.
Breast Cancer Res. Treat. 43:247-258(1997)

PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2
MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H., Drexler H.G.
Widespread intraspecies cross-contamination of human tumor cell lines arising at source.
Int. J. Cancer 83:555-563(1999)

PubMed=10700188; DOI=10.1038/73536
Gayther S.A., Batley S.J., Linger L., Bannister A., Thorpe K., Chin S.-F., Daigo Y., Russell P., Wilson A., Sowter H.M., Delhanty J.D.A., Ponder B.A.J., Kouzarides T., Caldas C.
Mutations truncating the EP300 acetylase in human cancers.
Nat. Genet. 24:300-303(2000)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151742
Other Wikidata; Q54904065
Polymorphism and mutation databases Cosmic; 1523956
Cosmic; 1523973