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Cellosaurus LC-1/sq-SF (CVCL_5480)

[Text version]

Cell line name LC-1/sq-SF
Synonyms LC1_sq-SF; LC-1-sq-SF; LC1SQSF; LC-1/sq-Serum Free
Accession CVCL_5480
Resource Identification Initiative To cite this cell line use: LC-1/sq-SF (RRID:CVCL_5480)
Comments Group: Serum/protein free medium cell line.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for SPEN p.Arg1475Ter (c.4423C>T) (CCLE).
Homozygous for TP53 p.Met237Ile (c.711G>T) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.68
Native American0
East Asian, North96.94
East Asian, South1.38
South Asian0
European, North0
European, South0
Disease Squamous cell lung carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3008 (LC-1/sq)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): RCB

Markers:
AmelogeninX
CSF1PO12
D5S81812,13
D7S82012
D13S31712,13
D16S5399
TH017,9
TPOX8,12
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB0438
Cell line databases/resources CCLE; LC1SQSF_LUNG
Cell_Model_Passport; SIDM01226
DepMap; ACH-001113
Ontologies CLO; CLO_0050066
Biological sample resources BioSample; SAMN10988019
Chemistry resources PharmacoDB; LC1/sqSF_829_2019
Gene expression databases GEO; GSM887263
GEO; GSM888338
Other Wikidata; Q54902122
Polymorphism and mutation databases Cosmic; 2125266
IARC_TP53; 30112
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number16