ID   MCF10DCIS.com
AC   CVCL_5552
SY   MCF10DCIS.COM; MCF10ADCIS.com; MCF10A-DCIS.com; MCF10DCIS; MCFDCIS; DCIS.COM; DCIS
DR   EFO; EFO_0006643
DR   ArrayExpress; E-MTAB-2706
DR   cancercelllines; CVCL_5552
DR   Cosmic; 1219447
DR   EGA; EGAS00001000610
DR   GEO; GSM271345
DR   GEO; GSM271398
DR   Lonza; 1619
DR   MetaboLights; MTBLS669
DR   PharmacoDB; MCF10DCIS_com_892_2019
DR   Progenetix; CVCL_5552
DR   Wikidata; Q54904447
RX   PubMed=10904098;
RX   PubMed=18455123;
RX   PubMed=23401782;
RX   PubMed=25485619;
RX   PubMed=34238275;
CC   Characteristics: Derived from a xenograft originating from MCF-10AT cells that were injected into severe combined immune-deficient mice.
CC   Doubling time: 20.5 hours (PubMed=34238275).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Unspecified (PubMed=23401782).
CC   Transfected with: HGNC; 5173; HRAS (with p.Gly12Val).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5555 ! MCF-10AT
SX   Female
AG   36Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 28
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RX   PubMed=10904098; DOI=10.1093/jnci/92.14.1185A;
RA   Miller F.R., Santner S.J., Tait L., Dawson P.J.;
RT   "MCF10DCIS.com xenograft model of human comedo ductal carcinoma in
RT   situ.";
RL   J. Natl. Cancer Inst. 92:1185-1186(2000).
//
RX   PubMed=18455123; DOI=10.1016/j.ccr.2008.03.007;
RA   Hu M., Yao J., Carroll D.K., Weremowicz S., Chen H.-Y., Carrasco D.,
RA   Richardson A., Violette S.M., Nikolskaya T., Nikolsky Y.,
RA   Bauerlein E.L., Hahn W.C., Gelman R.S., Allred C., Bissell M.J.,
RA   Schnitt S., Polyak K.;
RT   "Regulation of in situ to invasive breast carcinoma transition.";
RL   Cancer Cell 13:394-406(2008).
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RX   PubMed=23401782; DOI=10.1155/2013/872743;
RA   Barnabas N., Cohen D.;
RT   "Phenotypic and molecular characterization of MCF10DCIS and SUM breast
RT   cancer cell lines.";
RL   Int. J. Breast Cancer 2013:872743.1-872743.16(2013).
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RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
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RX   PubMed=34238275; DOI=10.1186/s12885-021-08511-2;
RA   Samson J., Derlipanska M., Zaheed O., Dean K.;
RT   "Molecular and cellular characterization of two patient-derived ductal
RT   carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC-010.";
RL   BMC Cancer 21:790.1-790.20(2021).
//