Home  |  Contact

Cellosaurus ZR-75-B (CVCL_5614)

[Text version]

Cell line name ZR-75-B
Synonyms ZR75-B; ZR-75B; ZR-75b; ZR75B
Accession CVCL_5614
Resource Identification Initiative To cite this cell line use: ZR-75-B (RRID:CVCL_5614)
Comments Part of: GrayJW breast cancer cell line panel.
Population: Caucasian.
Doubling time: 30.5 hours (PubMed=8562478; PubMed=9815641); 44.80 hours (https://www.synapse.org/#!Synapse:syn2347014).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: ZRB75; Occasionally.
Sequence variations Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
HLA typing Source: PubMed=25960936
Class I
HLA-BB*35:01,35:01
HLA-CC*04:01,04:01
Class II
HLA-DQDQB1*05:01,05:01
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Children:
CVCL_ZZ26 (ZR75B Ad120)CVCL_ZZ27 (ZR75B Ad24)CVCL_ZZ28 (ZR75B Tx10)
CVCL_ZZ29 (ZR75B Tx40)CVCL_ZZ30 (ZR75B Vb10)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Publications

PubMed=6178756; DOI=10.1172/JCI110624
Jolivet J., Schilsky R.L., Bailey B.D., Drake J.C., Chabner B.A.
Synthesis, retention, and biological activity of methotrexate polyglutamates in cultured human breast cancer cells.
J. Clin. Invest. 70:351-360(1982)

PubMed=8562478
Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M., Gudas J.M., Bates S.E.
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

PubMed=9815641
Wosikowski K., Schuurhuis D., Kops G.J.P.L., Saceda M., Bates S.E.
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008
Neve R.M., Chin K., Fridlyand J., Yeh J., Baehner F.L., Fevr T., Clark L., Bayani N., Coppe J.-P., Tong F., Speed T., Spellman P.T., DeVries S., Lapuk A., Wang N.J., Kuo W.-L., Stilwell J.L., Pinkel D., Albertson D.G., Waldman F.M., McCormick F., Dickson R.B., Johnson M.D., Lippman M.E., Ethier S.P., Gazdar A.F., Gray J.W.
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004
Kenny P.A., Lee G.Y., Myers C.A., Neve R.M., Semeiks J.R., Spellman P.T., Lorenz K., Lee E.H., Barcellos-Hoff M.H., Petersen O.W., Gray J.W., Bissell M.J.
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
Mol. Oncol. 1:84-96(2007)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020
Timmerman L.A., Holton T., Yuneva M., Louie R.J., Padro M., Daemen A., Hu M., Chan D.A., Ethier S.P., van 't Veer L.J., Polyak K., McCormick F., Gray J.W.
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3
Prat A., Karginova O., Parker J.S., Fan C., He X., Bixby L., Harrell J.C., Roman E., Adamo B., Troester M., Perou C.M.
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

Cross-references
Cell line databases/resources DepMap; ACH-002331
LINCS_HMS; 51096
LINCS_LDP; LCL-2077
Ontologies EFO; EFO_0001264
Chemistry resources PharmacoDB; ZR75B_1691_2019
Gene expression databases ArrayExpress; E-TABM-157
ArrayExpress; E-TABM-244
GEO; GSM1053730
GEO; GSM1172910
GEO; GSM1173006
GEO; GSM1215271
Other Wikidata; Q54996122
Polymorphism and mutation databases Cosmic; 1136345
Cosmic; 1176641
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number23