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Cellosaurus MEL-CLS-1 (CVCL_5619)

[Text version]

Cell line name MEL-CLS-1
Synonyms FO-1; FO #1; FO 1
Accession CVCL_5619
Resource Identification Initiative To cite this cell line use: MEL-CLS-1 (RRID:CVCL_5619)
Comments Population: Caucasian.
Characteristics: Established from a xenograft (CLS).
Doubling time: 38 hours, at 49th passage (PubMed=994214).
Sequence variations Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (CLS).
Disease Amelanotic melanoma (NCIt: C3802)
Derived from metastatic site: Iliac lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_GZ38 (FO1-12)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): CLS

Markers:
AmelogeninX
CSF1PO10,12
D3S135815,18
D5S81812,13
D7S8209,11
D8S117912,14
D13S31712
D16S5399,12
D18S5117
D21S1127
FGA19,23
Penta D9
Penta E14,17
TH019
TPOX8
vWA17,18

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Publications

PubMed=994214; DOI=10.1093/jnci/56.6.1131
Glovanella B.C., Stehlin J.S. Jr., Santamaria C., Yim S.O., Morgan A.C., Williams L.J. Jr., Leibovitz A., Fialkow P.J., Mumford D.M.
Human neoplastic and normal cells in tissue culture. I. Cell lines derived from malignant melanomas and normal melanocytes.
J. Natl. Cancer Inst. 56:1131-1142(1976)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2624919; DOI=10.1007/BF01744892
Guarini L., Temponi M., Edwalds G.M., Vita J.R., Fisher P.B., Ferrone S.
In vitro differentiation and antigenic changes in human melanoma cell lines.
Cancer Immunol. Immunother. 30:262-268(1989)

PubMed=1898655; DOI=10.1172/JCI114984
D'Urso C.M., Wang Z.-G., Cao Y., Tatake R., Zeff R.A., Ferrone S.
Lack of HLA class I antigen expression by cultured melanoma cells FO-1 due to a defect in B2m gene expression.
J. Clin. Invest. 87:284-292(1991)

PubMed=8537970; DOI=10.1093/jnci/88.2.100
Restifo N.P., Marincola F.M., Kawakami Y., Taubenberger J.K., Yannelli J.R., Rosenberg S.A.
Loss of functional beta 2-microglobulin in metastatic melanomas from five patients receiving immunotherapy.
J. Natl. Cancer Inst. 88:100-108(1996)

PubMed=15661905; DOI=10.4049/jimmunol.174.3.1462
Chang C.-C., Campoli M., Restifo N.P., Wang X., Ferrone S.
Immune selection of hot-spot beta 2-microglobulin gene mutations, HLA-A2 allospecificity loss, and antigen-processing machinery component down-regulation in melanoma cells derived from recurrent metastases following immunotherapy.
J. Immunol. 174:1462-1471(2005)

Cross-references
Cell line collections CLS; 300175/p647_MEL-CLS-1
Ontologies BTO; BTO:0002943
Other Wikidata; Q54905083
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number17