Cellosaurus cell line A375-SM (CVCL_5649)

• Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  

PubMed=2297053
Schackert G., Price J.E., Zhang R.-D., Bucana C.D., Itoh K., Fidler I.J.
Regional growth of different human melanomas as metastases in the brain of nude mice.
Am. J. Pathol. 136:95-102(1990)

PubMed=1826230
Zhang R.-D., Price J.E., Schackert G., Itoh K., Fidler I.J.
Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.
Cancer Res. 51:2029-2035(1991)

PubMed=7648437; DOI=10.1089/jir.1995.15.81
Singh R.K., Gutman M., Radinsky R.
Heterogeneity of cytokine and growth factor gene expression in human melanoma cells with different metastatic potentials.
J. Interferon Cytokine Res. 15:81-87(1995)

PubMed=22323893; DOI=10.3109/10623329609024685
Sriramarao P., Bourdon M.A.
Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression.
Endothelium 4:85-97(1996)