Cellosaurus BJAB (CVCL_5711)

Cell line name BJAB
Synonyms BJAb; BJA-B; BJAB-1; BJA-B1; BJA-B-1
Accession CVCL_5711
Resource Identification Initiative To cite this cell line use: BJAB (RRID:CVCL_5711)
Comments Characteristics: EBV-negative.
Doubling time: ~40-60 hours (DSMZ).
Sequence variation: TP53 p.His193Arg (PubMed=8344493).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Disease Burkitt lymphoma (NCIt: C2912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_8659 (BBF); CVCL_IZ94 (BJAB-K20); CVCL_9876 (BJAB-K3); CVCL_IZ95 (BJAB-K43); CVCL_9666 (BJAB-K5); CVCL_IZ96 (BJAB-K6); CVCL_IZ97 (BJAB-K88); CVCL_8660 (BREM); CVCL_5758 (GC-BJAB); CVCL_1G52 (TF228.1.16)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO8,10
D13S3179,11
D16S5399,11
D18S5116,22
D21S1127,28
D3S135816
D5S81812,13
D7S82010,11
D8S117915
FGA27,28
Penta D10,11
Penta E7
TH017
TPOX6,9
vWA14,15 (DSMZ)
14,16 (PubMed=25877200)
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-73.html
Publications

PubMed=4369887; DOI=10.1073/pnas.71.8.3283
Klein G., Lindahl T., Jondal M., Leibold W., Menezes J., Nilsson K., Sundstrom C.
Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas.
Proc. Natl. Acad. Sci. U.S.A. 71:3283-3286(1974)

PubMed=171663; DOI=10.1073/pnas.72.9.3518
Steinitz M., Klein G.
Comparison between growth characteristics of an Epstein-Barr virus (EBV)-genome-negative lymphoma line and its EBV-converted subline in vitro.
Proc. Natl. Acad. Sci. U.S.A. 72:3518-3520(1975)

PubMed=179629
Menezes J., Leibold W., Klein G., Clements G.
Establishment and characterization of an Epstein-Barr virus (EBV)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma.
Biomedicine 22:276-284(1975)

PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x
Povey S., Jeremiah S., Arthur E., Steel M., Klein G.
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Ann. Hum. Genet. 44:119-133(1980)

PubMed=6286763
Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd H.D., Parsons R.G.
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)

PubMed=6600440; DOI=10.1007/BF02617996
Uittenbogaart C.H., Cantor Y., Fahey J.L.
Growth of human malignant lymphoid cell lines in serum-free medium.
In Vitro 19:67-72(1983)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3495441; DOI=10.1002/eji.1830170503
Kanowith-Klein S., Saxon A., Uittenbogaart C.H.
Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.
Eur. J. Immunol. 17:593-598(1987)

PubMed=1915267
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=8344493
Bhatia K., Goldschmidts W., Gutierrez M.I., Gaidano G., Dalla-Favera R., Magrath I.T.
Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.
FASEB J. 7:951-956(1993)

PubMed=8515068
Jain V.K., Judde J.-G., Max E.E., Magrath I.T.
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=23292937; DOI=10.1073/pnas.1205299110
Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L., Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G., Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P., Flowers C., Naresh K., Evens A., Gordon L.I., Czader M., Gill J.I., Hsi E.D., Liu Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J., Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S., Dunson D., Dave S.S.
Genetic heterogeneity of diffuse large B-cell lymphoma.
Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections AddexBio; C0003016/4884
DSMZ; ACC-757
Cell line databases/resources CGH-DB; 9192-4
Lonza; 107
TOKU-E; 3575
Ontologies BTO; BTO:0001931
EFO; EFO_0002815
Biological sample resources BioSample; SAMN03470800
Chemistry resources ChEMBL-Cells; CHEMBL3308492
ChEMBL-Targets; CHEMBL613536
Gene expression databases GEO; GSM710427
GEO; GSM710443
GEO; GSM1059805
Polymorphism and mutation databases Cosmic; 998715
Cosmic; 1019312
Cosmic; 1037700
Cosmic; 1086323
Cosmic; 1127265
Cosmic; 1517659
Cosmic; 1588562
Cosmic; 1945179