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Cellosaurus CH-157MN (CVCL_5723)

[Text version]

Cell line name CH-157MN
Synonyms CH157-MN; CH-157-MN; CH-157 MN; CH157MN
Accession CVCL_5723
Resource Identification Initiative To cite this cell line use: CH-157MN (RRID:CVCL_5723)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 22 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: shRNA library screening.
Caution: Indicated to be from a 41 year old female patient in PubMed=7714613, from a 59 year old in PubMed=10083766 and from a 55 year old in PubMed=18261772.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North2.54
East Asian, South0
South Asian0.15
European, North57.82
European, South38.99
Disease Meningioma (NCIt: C3230)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HA68 (CH-157MN-LucNeo)
Sex of cell Female
Age at sampling 41Y
Category Cancer cell line

PubMed=7714613; DOI=10.3171/jns.1995.82.5.0864
Tsai J.-C., Goldman C.K., Gillespie G.Y.
Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF.
J. Neurosurg. 82:864-873(1995)

Tsai J.-C., Hsiao Y.-Y., Teng L.-J., Shun C.-T., Chen C.-T., Goldman C.K., Kao M.-C.
Regulation of vascular endothelial growth factor secretion in human meningioma cells.
J. Formos. Med. Assoc. 98:111-117(1999)

PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031
Ragel B.T., Couldwell W.T., Gillespie D.L., Wendland M.M., Whang K., Jensen R.L.
A comparison of the cell lines used in meningioma research.
Surg. Neurol. 70:295-307(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=28552950; DOI=10.1371/journal.pone.0178322
Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y., Beroukhim R., Dunn G.P., Dunn I.F.
Genomic profile of human meningioma cell lines.
PLoS ONE 12:E0178322-E0178322(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line databases/resources CCLE; CH157MN_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM01543
DepMap; ACH-000025
Biological sample resources BioSample; SAMN10988423
Chemistry resources PharmacoDB; CH157MN_195_2019
Other Wikidata; Q54811594
Polymorphism and mutation databases Cosmic; 2516046
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number16