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Cellosaurus IOMM-Lee (CVCL_5779)

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Cell line name IOMM-Lee
Synonyms IOMM-LEE; Iomm-Lee; IOMM Lee; IOMMLEE; IntraOsseous Malignant Meningioma-Lee
Accession CVCL_5779
Resource Identification Initiative To cite this cell line use: IOMM-Lee (RRID:CVCL_5779)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Population: Chinese.
Doubling time: ~62 hours (PubMed=2234331); 18 hours (PubMed=25984343); 22 hours (ATCC).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: shRNA library screening.
Derived from sampling site: Brain.
Sequence variations Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (CCLE).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).
Disease Intracranial meningioma (NCIt: C4656)
Meningioma (ORDO: Orphanet_2495)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HA67 (IOMM-Lee-LucNeo)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
STR profile Source(s): ATCC


Run an STR similarity search on this cell line

PubMed=2234331; DOI=10.1097/00006123-199009000-00008
Lee W.-H.
Characterization of a newly established malignant meningioma cell line of the human brain: IOMM-Lee.
Neurosurgery 27:389-395(1990)

PubMed=16554968; DOI=10.1007/s11060-005-9076-y
Baia G.S., Slocum A.L., Hyer J.D., Misra A., Sehati N., VandenBerg S.R., Feuerstein B.G., Deen D.F., McDermott M.W., Lal A.
A genetic strategy to overcome the senescence of primary meningioma cell cultures.
J. Neurooncol. 78:113-121(2006)

PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031
Ragel B.T., Couldwell W.T., Gillespie D.L., Wendland M.M., Whang K., Jensen R.L.
A comparison of the cell lines used in meningioma research.
Surg. Neurol. 70:295-307(2008)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=28552950; DOI=10.1371/journal.pone.0178322
Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y., Beroukhim R., Dunn G.P., Dunn I.F.
Genomic profile of human meningioma cell lines.
PLoS ONE 12:E0178322-E0178322(2017)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections ATCC; CRL-3370
Cell line databases/resources CCLE; IOMMLEE_CENTRAL_NERVOUS_SYSTEM
DepMap; ACH-000629
Ontologies BTO; BTO:0004464
Biological sample resources BioSample; SAMN10988414
Chemistry resources PharmacoDB; IOMMLee_661_2019
Other Wikidata; Q54897853
Polymorphism and mutation databases Cosmic; 2516047
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number15