ID   IOMM-Lee
AC   CVCL_5779
SY   IOMM-LEE; Iomm-Lee; IOMM Lee; IOMMLEE; IntraOsseous Malignant Meningioma-Lee
DR   BTO; BTO:0004464
DR   ATCC; CRL-3370
DR   BioSample; SAMN10988414
DR   cancercelllines; CVCL_5779
DR   Cell_Model_Passport; SIDM01733
DR   Cosmic; 2516047
DR   DepMap; ACH-000629
DR   PharmacoDB; IOMMLee_661_2019
DR   Wikidata; Q54897853
RX   PubMed=2234331;
RX   PubMed=16554968;
RX   PubMed=18261772;
RX   PubMed=25984343;
RX   PubMed=28552950;
RX   PubMed=31068700;
RX   PubMed=34850056;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Chinese.
CC   Doubling time: ~62 hours (PubMed=2234331); 18 hours (PubMed=25984343); 0.8 day (PubMed=34850056); 22 hours (ATCC=CRL-3370).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (DepMap).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=28552950).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 8,9
ST   D16S539: 12,13
ST   D5S818: 11,13
ST   D7S820: 11,12
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 17,18
DI   NCIt; C4656; Intracranial meningioma
DI   ORDO; Orphanet_2495; Meningioma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 19
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RX   PubMed=2234331; DOI=10.1097/00006123-199009000-00008;
RA   Lee W.-H.;
RT   "Characterization of a newly established malignant meningioma cell
RT   line of the human brain: IOMM-Lee.";
RL   Neurosurgery 27:389-395(1990).
//
RX   PubMed=16554968; DOI=10.1007/s11060-005-9076-y;
RA   Baia G.S., Slocum A.L., Hyer J.D., Misra A., Sehati N.,
RA   VandenBerg S.R., Feuerstein B.G., Deen D.F., McDermott M.W., Lal A.;
RT   "A genetic strategy to overcome the senescence of primary meningioma
RT   cell cultures.";
RL   J. Neurooncol. 78:113-121(2006).
//
RX   PubMed=18261772; DOI=10.1016/j.surneu.2007.06.031;
RA   Ragel B.T., Couldwell W.T., Gillespie D.L., Wendland M.M., Whang K.,
RA   Jensen R.L.;
RT   "A comparison of the cell lines used in meningioma research.";
RL   Surg. Neurol. 70:295-307(2008).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=28552950; DOI=10.1371/journal.pone.0178322;
RA   Mei Y., Bi W.-Y.L., Greenwald N.F., Agar N.Y., Beroukhim R., Dunn G.P.,
RA   Dunn I.F.;
RT   "Genomic profile of human meningioma cell lines.";
RL   PLoS ONE 12:E0178322-E0178322(2017).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=34850056; DOI=10.1093/jnen/nlab111;
RA   Uhlmann E.J., Rabinovsky R., Varma H., El Fatimy R., Kasper E.M.,
RA   Moore J.M., Vega R.A., Thomas A.J., Alterman R.L., Stippler M.,
RA   Anderson M.P., Uhlmann E.N., Kipper F.C., Krichevsky A.M.;
RT   "Tumor-derived cell culture model for the investigation of meningioma
RT   biology.";
RL   J. Neuropathol. Exp. Neurol. 80:1117-1124(2021).
//