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Cellosaurus LX-2 (CVCL_5792)

[Text version]

Cell line name LX-2
Synonyms Lieming Xu-2
Accession CVCL_5792
Resource Identification Initiative To cite this cell line use: LX-2 (RRID:CVCL_5792)
Comments Characteristics: Able to grow under reduced serum conditions (1% FBS) (PubMed=15591520).
Doubling time: ~3-4 days (PubMed=15591520).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Extracellular matrix proteome analysis.
Anecdotal: Cell line name is derived from the name of the first author of the original paper.
Derived from sampling site: Liver; hepatic stellate cells.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5790 (LX-1 [Human HSC])
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): Genomics_Center_BCF_Technion; Millipore; PubMed=24116068

Markers:
AmelogeninX,Y
CSF1PO10,12
D1S165612
D2S44111,14
D2S133817
D3S135813,15
D5S81811,12
D7S82011
D8S117913
D10S124813
D12S39115,17
D13S31711,13
D16S53913
D18S5112
D19S43313,15.2
D21S1128,31
D22S104516
DYS39110
FGA21,26
Penta D12,13,15
Penta E5,21
TH019.3
TPOX8,9
vWA17

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Publications

PubMed=15591520; DOI=10.1136/gut.2004.042127
Xu L.-M., Hui A.Y., Albanis E., Arthur M.J., O'Byrne S.M., Blaner W.S., Mukherjee P., Friedman S.L., Eng F.J.
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.
Gut 54:142-151(2005)

PubMed=17760834; DOI=10.1111/j.1582-4934.2007.00060.x
Herrmann J., Gressner A.M., Weiskirchen R.
Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
J. Cell. Mol. Med. 11:704-722(2007)

PubMed=19085953; DOI=10.1002/hep.22697
Guo J., Loke J., Zheng F., Hong F., Yea S., Fukata M., Tarocchi M., Abar O.T., Huang H., Sninsky J.J., Friedman S.L.
Functional linkage of cirrhosis-predictive single nucleotide polymorphisms of Toll-like receptor 4 to hepatic stellate cell responses.
Hepatology 49:960-968(2009)

PubMed=22694338; DOI=10.1021/pr3000927
Rashid S.T., Humphries J.D., Byron A., Dhar A., Askari J.A., Selley J.N., Knight D., Goldin R.D., Thursz M., Humphries M.J.
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver.
J. Proteome Res. 11:4052-4064(2012)

PubMed=24116068; DOI=10.1371/journal.pone.0075692
Weiskirchen R., Weimer J., Meurer S.K., Kron A., Seipel B., Vater I., Arnold N., Siebert R., Xu L.-M., Friedman S.L., Bergmann C.
Genetic characteristics of the human hepatic stellate cell line LX-2.
PLoS ONE 8:E75692-E75692(2013)

Cross-references
Cell line collections Millipore; SCC064
Cell line databases/resources Lonza; 616
SKY/M-FISH/CGH; 5853
Ontologies BTO; BTO:0003516
Other Wikidata; Q54903298
Proteomic databases PRIDE; PRD000680
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number17