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Cellosaurus KTCTL-140 (CVCL_5879)

[Text version]

Cell line name KTCTL-140
Synonyms KTCTL140; RCC-JF; RCCJF
Accession CVCL_5879
Resource Identification Initiative To cite this cell line use: KTCTL-140 (RRID:CVCL_5879)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Misspelling: KTCL140; In Cosmic 972926 and PubMed=7915601.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.77
East Asian, North2.03
East Asian, South0
South Asian1.72
European, North62.07
European, South33.41
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): CLS; Cosmic-CLP

Markers:
AmelogeninX
CSF1PO10,13
D3S135817
D5S81811
D7S8207,8
D8S117912,14
D13S31711,12
D16S53911
D18S5113,15
D21S1128,30.2
FGA18,25
Penta D10,13
Penta E7,13
TH017,9
TPOX8
vWA18

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=7915601; DOI=10.1038/ng0594-85
Gnarra J.R., Tory K., Weng Y., Schmidt L., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C., Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H., Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B., Linehan W.M.
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)

PubMed=11762795; DOI=10.1007/s002400100214
Siebels M., Meyer G., Habicht A., Meuer S.C., Moebius U.
Simultaneous ligation of CD5 and CD28 with monoclonal antibodies restores impaired immunostimulatory function in human renal cell carcinoma.
Urol. Res. 29:330-337(2001)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28489074; DOI=10.1038/ncomms15165
Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y., Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C., Hsieh J.J., Hakimi A.A.
Analysis of renal cancer cell lines from two major resources enables genomics-guided cell line selection.
Nat. Commun. 8:15165-15165(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections CLS; 300274/p673_RCC-JF
Cell line databases/resources CCLE; RCCJF_KIDNEY
Cell_Model_Passport; SIDM00818
Cosmic-CLP; 1524415
DepMap; ACH-002190
Chemistry resources GDSC; 1524415
PharmacoDB; RCCJF_1290_2019
Gene expression databases ArrayExpress; E-MTAB-3610
Other Wikidata; Q54900633
Polymorphism and mutation databases Cosmic; 972926
Cosmic; 1352063
Cosmic; 1751974
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number23