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Cellosaurus KM12-OxR (CVCL_5920)

[Text version]

Cell line name KM12-OxR
Synonyms KM12L4 OxR
Accession CVCL_5920
Resource Identification Initiative To cite this cell line use: KM12-OxR (RRID:CVCL_5920)
Comments Selected for resistance to: ChEBI; CHEBI:31941; Oxaliplatin (Elotaxin; L-OHP).
Sequence variations TPM3-NTRK1 gene fusion (from parent cell line).
Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for APC p.Asn1819fs*7 (c.5454_5455insA) (from parent cell line).
Heterozygous for BRCA2 p.Asn1784Hisfs*7 (c.5350_5351delAA) (from parent cell line).
Heterozygous for PTEN p.Gly129Ter (c.385G>T) and p.Lys267fs*9 (c.800delA) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Heterozygous for TP53 p.Arg72fs*51 (c.215delG) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5946 (KM12-L4)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

PubMed=16857785; DOI=10.1158/1078-0432.CCR-06-0038
Yang A.D., Fan F., Camp E.R., van Buren G. II, Liu W., Somcio R., Gray M.J., Cheng H., Hoff P.M., Ellis L.M.
Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines.
Clin. Cancer Res. 12:4147-4153(2006)

Other Wikidata; Q54900061
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number12