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Cellosaurus KM12-L4 (CVCL_5946)

Cell line name KM12-L4
Synonyms KM12L4; Km12L4; KM12 L4; Km 12 L4
Accession CVCL_5946
Resource Identification Initiative To cite this cell line use: KM12-L4 (RRID:CVCL_5946)
Comments Microsatellite instability: Instable (MSI) (PubMed=25926053).
Omics: Transcriptome analysis.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
Heterozygous for APC p.Asn1819fs*7 (c.5454_5455insA) (from parent cell line).
Heterozygous for BRCA2 p.Asn1784Hisfs*7 (c.5350_5351delAA) (from parent cell line).
Heterozygous for PTEN p.Gly129Ter (c.385G>T) and p.Lys267fs*9 (c.800delA) (from parent cell line).
Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Heterozygous for TP53 p.Arg72fs*51 (c.215delG) (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1331 (KM12)
Children:
CVCL_W220 (KM12-L4A)CVCL_5920 (KM12-OxR)CVCL_AU12 (KM12L4/OXR)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25926053

Markers:
AmelogeninX
CSF1PO10,12
D13S31713,15
D16S53911,12
D21S1127,34
D5S81811
D7S8208,9
TH0110
TPOX11,12
vWA16,17
Publications

PubMed=2846163
Morikawa K., Walker S.M., Nakajima M., Pathak S., Jessup J.M., Fidler I.J.
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.
Cancer Res. 48:6863-6871(1988)

PubMed=3349467
Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988)

PubMed=8909255
Goetz D.J., Ding H., Atkinson W.J., Vachino G., Camphausen R.T., Cumming D.A., Luscinskas F.W.
A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism.
Am. J. Pathol. 149:1661-1673(1996)

PubMed=10091941; DOI=10.1023/A:1006537609469
Nakayama Y., Okazaki K., Shibao K., Sako T., Hirata K., Nagata N., Kuwano M., Itoh H.
Alterative expression of the collagenase and adhesion molecules in the highly metastatic clones of human colonic cancer cell lines.
Clin. Exp. Metastasis 16:461-469(1998)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

Cross-references
Cell line collections KCLB; 80014
Gene expression databases GEO; GSM1448187
Other Wikidata; Q54900057