ID   KM12-L4
AC   CVCL_5946
SY   KM12L4; Km12L4; KM12 L4; Km 12 L4
DR   GEO; GSM1448187
DR   KCLB; 80014
DR   Wikidata; Q54900057
RX   PubMed=2846163;
RX   PubMed=3349467;
RX   PubMed=8909255;
RX   PubMed=10091941;
RX   PubMed=25926053;
CC   Microsatellite instability: Instable (MSI) (PubMed=25926053).
CC   Sequence variation: TPM3-NTRK1 gene fusion (from parent cell line).
CC   Sequence variation: Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
CC   Sequence variation: Heterozygous for APC p.Asn1819fs*7 (c.5454_5455insA) (from parent cell line).
CC   Sequence variation: Heterozygous for BRCA2 p.Asn1784Hisfs*7 (c.5350_5351delAA) (from parent cell line).
CC   Sequence variation: Heterozygous for PTEN p.Gly129Ter (c.385G>T) and p.Lys267fs*9 (c.800delA) (from parent cell line).
CC   Sequence variation: Heterozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
CC   Sequence variation: Heterozygous for TP53 p.Arg72fs*51 (c.215delG) (from parent cell line).
CC   Omics: Transcriptome analysis.
ST   Source(s): PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 13,15
ST   D16S539: 11,12
ST   D21S11: 27,34
ST   D5S818: 11
ST   D7S820: 8,9
ST   TH01: 10
ST   TPOX: 11,12
ST   vWA: 16,17
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1331 ! KM12
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-07-19; Version: 15
RX   PubMed=2846163;
RA   Morikawa K., Walker S.M., Nakajima M., Pathak S., Jessup J.M.,
RA   Fidler I.J.;
RT   "Influence of organ environment on the growth, selection, and
RT   metastasis of human colon carcinoma cells in nude mice.";
RL   Cancer Res. 48:6863-6871(1988).
RX   PubMed=3349467;
RA   Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.;
RT   "In vivo selection of highly metastatic cells from surgical specimens
RT   of different primary human colon carcinomas implanted into nude
RT   mice.";
RL   Cancer Res. 48:1943-1948(1988).
RX   PubMed=8909255;
RA   Goetz D.J., Ding H., Atkinson W.J., Vachino G., Camphausen R.T.,
RA   Cumming D.A., Luscinskas F.W.;
RT   "A human colon carcinoma cell line exhibits adhesive interactions with
RT   P-selectin under fluid flow via a PSGL-1-independent mechanism.";
RL   Am. J. Pathol. 149:1661-1673(1996).
RX   PubMed=10091941; DOI=10.1023/A:1006537609469;
RA   Nakayama Y., Okazaki K., Shibao K., Sako T., Hirata K., Nagata N.,
RA   Kuwano M., Itoh H.;
RT   "Alterative expression of the collagenase and adhesion molecules in
RT   the highly metastatic clones of human colonic cancer cell lines.";
RL   Clin. Exp. Metastasis 16:461-469(1998).
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002-7002(2015).