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Cellosaurus JHU-013 (CVCL_5988)

[Text version]

Cell line name JHU-013
Synonyms JHU 013; JHU013; JHU-O13; JHU-13; O13
Accession CVCL_5988
Resource Identification Initiative To cite this cell line use: JHU-013 (RRID:CVCL_5988)
Comments Problematic cell line: Contaminated. Shown to be a FaDu derivative (PubMed=21868764).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00404.
Population: Indian.
Derived from sampling site: Hypopharynx.
Sequence variations Homozygous for CDKN2A c.151-1G>T (ClinVar=VCV000422058); Note=Splice acceptor mutation (from parent cell line).
Heterozygous for FAT1 p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs) (from parent cell line).
Heterozygous for TP53 p.Arg248Leu (c.743G>T) (ClinVar=VCV000230253) (from parent cell line).
Heterozygous for TP53 c.376-1G>A (p.Tyr126_Lys132del; c.376_396del21) (ClinVar=VCV000481003); Note=Splice acceptor mutation (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764


Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx

PubMed=12925955; DOI=10.1002/ijc.11341
Minhas K.M., Singh B., Jiang W.W., Sidransky D., Califano J.A.
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E., Sidransky D.
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Ontologies BTO; BTO:0003890
Biological sample resources BioSample; SAMN03151639
Chemistry resources PharmacoDB; JHU013_693_2019
Other Wikidata; Q54898669
Polymorphism and mutation databases Cosmic; 1122670
Cosmic; 1530747
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number22