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Cellosaurus JHU-028 (CVCL_5992)

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Cell line name JHU-028
Synonyms JHU 028; JHU028; SCC028; HNSCC 028; O28
Accession CVCL_5992
Resource Identification Initiative To cite this cell line use: JHU-028 (RRID:CVCL_5992)
Comments Problematic cell line: Contaminated. Shown to be a A-549 derivative (PubMed=21868764). Originally thought to originate from a base of tongue squamous cell carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00406.
Omics: Deep exome analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for KRAS p.Gly12Ser (c.34G>A) (DepMap).
Homozygous for STK11 p.Gln37Ter (c.109C>T) (DepMap).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764


Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx

PubMed=12925955; DOI=10.1002/ijc.11341
Minhas K.M., Singh B., Jiang W.W., Sidransky D., Califano J.A.
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E., Sidransky D.
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cell line databases/resources Cell_Model_Passport; SIDM00902
DepMap; ACH-002337
Biological sample resources BioSample; SAMN03151610
Chemistry resources GDSC; 1298154
PharmacoDB; JHU028_696_2019
Gene expression databases ArrayExpress; E-MTAB-3610
Other Wikidata; Q54898675
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number14