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Cellosaurus MDA231-LM2-4175 (CVCL_5998)

[Text version]

Cell line name MDA231-LM2-4175
Synonyms MDA231-LM2; MDA 231-LM2-4175; MDA-MB-231 #4175; LM2-4175; 4175
Accession CVCL_5998
Resource Identification Initiative To cite this cell line use: MDA231-LM2-4175 (RRID:CVCL_5998)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Characteristics: Established from MDA231-TGL cell line after 3 passage in nude mice.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Omics: Proteome analysis by 2D-DE.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR35 (MDA231-TGL)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO12,13
D1S165615,17
D2S44114,15
D2S133820,21
D3S135816
D5S81812
D7S8208
D8S117913
D10S124816
D12S39117,18
D13S31713
D16S53912
D18S5111,16
D19S43311,14
D21S1133.2
D22S104515,16,17
FGA22,23
Penta D14
Penta E11
TH017,9.3
TPOX8,9
vWA15

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Publications

PubMed=16049480; DOI=10.1038/nature03799
Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W., Giri D.D., Viale A.J., Olshen A.B., Gerald W.L., Massague J.
Genes that mediate breast cancer metastasis to lung.
Nature 436:518-524(2005)

PubMed=18425382; DOI=10.3892/or.19.5.1237
Selicharova I., Sanda M., Mladkova J., Ohri S.S., Vashishta A., Fusek M., Jiracek J., Vetvicka V.
2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231.
Oncol. Rep. 19:1237-1244(2008)

Cross-references
Gene expression databases GEO; GSM49956
GEO; GSM587391
Other Wikidata; Q54904666
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number15