ID   MDA231-LM2-4175
AC   CVCL_5998
SY   MDA231-LM2; MDA 231-LM2-4175; MDA-MB-231 #4175; LM2-4175; 4175
DR   GEO; GSM49956
DR   GEO; GSM587391
DR   Wikidata; Q54904666
RX   PubMed=16049480;
RX   PubMed=18425382;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: Caucasian.
CC   Characteristics: Established from MDA231-TGL cell line after 3 passage in nude mice.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Omics: Proteome analysis by 2D-DE.
CC   Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): MSKCC
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D10S1248: 16
ST   D12S391: 17,18
ST   D13S317: 13
ST   D16S539: 12
ST   D18S51: 11,16
ST   D19S433: 11,14
ST   D1S1656: 15,17
ST   D21S11: 33.2
ST   D22S1045: 15,16,17
ST   D2S1338: 20,21
ST   D2S441: 14,15
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 8
ST   D8S1179: 13
ST   FGA: 22,23
ST   Penta D: 14
ST   Penta E: 11
ST   TH01: 7,9.3
ST   TPOX: 8,9
ST   vWA: 15
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_VR35 ! MDA231-TGL
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 23-09-21; Version: 20
//
RX   PubMed=16049480; DOI=10.1038/nature03799;
RA   Minn A.J., Gupta G.P., Siegel P.M., Bos P.D., Shu W.-P., Giri D.D.,
RA   Viale A.J., Olshen A.B., Gerald W.L., Massague J.;
RT   "Genes that mediate breast cancer metastasis to lung.";
RL   Nature 436:518-524(2005).
//
RX   PubMed=18425382; DOI=10.3892/or.19.5.1237;
RA   Selicharova I., Sanda M., Mladkova J., Ohri S.S., Vashishta A.,
RA   Fusek M., Jiracek J., Vetvicka V.;
RT   "2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct
RT   metastatic organ-specific potentials: comparison with parental cell
RT   line MDA-MB-231.";
RL   Oncol. Rep. 19:1237-1244(2008).
//