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Cellosaurus MCF-7/AnaR-4 (CVCL_5A12)

[Text version]

Cell line name MCF-7/AnaR-4
Synonyms MCF7/AnaR-4; AnaR-4
Accession CVCL_5A12
Resource Identification Initiative To cite this cell line use: MCF-7/AnaR-4 (RRID:CVCL_5A12)
Comments Selected for resistance to: ChEBI; CHEBI:2704; Anastrozole.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ECACC

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81811,12
D7S8209
D8S117910,14
D13S31711
D16S53911,12
D18S5114
D21S1130
FGA23,25
Penta D12
Penta E7,12
TH016
TPOX9,12
vWA14,15

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Publications

PubMed=25625755; DOI=10.3892/ijo.2015.2850
Hole S., Pedersen A.M., Hansen S.K., Lundqvist J., Yde C.W., Lykkesfeldt A.E.
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Int. J. Oncol. 46:1481-1490(2015)

Cross-references
Cell line collections ECACC; 16022519
Ximbio; 152554
Other Wikidata; Q54904356
Entry history
Entry creation14-Dec-2015
Last entry updated25-Feb-2019
Version number7