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Cellosaurus MCF-7/LetR-3 (CVCL_5A19)

[Text version]

Cell line name MCF-7/LetR-3
Synonyms MCF7/LetR-3; MCF-7/S0.5/LetR-3; LetR-3
Accession CVCL_5A19
Resource Identification Initiative To cite this cell line use: MCF-7/LetR-3 (RRID:CVCL_5A19)
Comments Selected for resistance to: ChEBI; CHEBI:6413; Letrozole.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=25625755; DOI=10.3892/ijo.2015.2850
Hole S., Pedersen A.M., Hansen S.K., Lundqvist J., Yde C.W., Lykkesfeldt A.E.
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Int. J. Oncol. 46:1481-1490(2015)

PubMed=25667100; DOI=10.1007/s10549-015-3284-8
Hole S., Pedersen A.M., Lykkesfeldt A.E., Yde C.W.
Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells.
Breast Cancer Res. Treat. 149:715-726(2015)

Cell line collections ECACC; 16022526
Ximbio; 152549
Other Wikidata; Q54904371
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7