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Cellosaurus MCF-7/LetR-4 (CVCL_5A20)

[Text version]

Cell line name MCF-7/LetR-4
Synonyms MCF7/LetR-4; LetR-4
Accession CVCL_5A20
Resource Identification Initiative To cite this cell line use: MCF-7/LetR-4 (RRID:CVCL_5A20)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:6413; Letrozole.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=25625755; DOI=10.3892/ijo.2015.2850
Hole S., Pedersen A.M., Hansen S.K., Lundqvist J., Yde C.W., Lykkesfeldt A.E.
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Int. J. Oncol. 46:1481-1490(2015)

Cross-references
Cell line collections Ximbio; 152550
Encyclopedic resources Wikidata; Q54904372
Entry history
Entry creation14-Dec-2015
Last entry update20-May-2021
Version number10