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Cellosaurus SVG-A (CVCL_5G13)

Cell line name SVG-A
Accession CVCL_5G13
Resource Identification Initiative To cite this cell line use: SVG-A (RRID:CVCL_5G13)
Comments Characteristics: Used to study trinucleotide repeat (TNR) expansion as these cells support expansiosns in culture.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pSVori-].
Omics: Transcriptome analysis by microarray.
Caution: In contrast to SVG p12 (Cellosaurus=CVCL_3797), this cell line is not contaminated with BK polyomavirus (PubMed=24760884).
Derived from site: In situ; Fetal brain; UBERON=UBERON_0006237.
Cell type: Astrocyte; CL=CL_0000127.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5G14 (SVG)
Children:
CVCL_C3HJ (SVG-A CHMP1A null)CVCL_VP18 (SVG-A Msh3-/-)CVCL_IM78 (SVGR2)
Sex of cell Male
Age at sampling 8-12FW
Category Transformed cell line
Publications

PubMed=11517388; DOI=10.1080/13550280152058816
Schweighardt B., Shieh J.T.C., Atwood W.J.
CD4/CXCR4-independent infection of human astrocytes by a T-tropic strain of HIV-1.
J. Neurovirol. 7:155-162(2001)

PubMed=14517064; DOI=10.1016/S0042-6822(03)00389-1
Gee G.V., Manley K., Atwood W.J.
Derivation of a JC virus-resistant human glial cell line: implications for the identification of host cell factors that determine viral tropism.
Virology 314:101-109(2003)

PubMed=16945950; DOI=10.1093/nar/gkl614
Farrell B.T., Lahue R.S.
CAG*CTG repeat instability in cultured human astrocytes.
Nucleic Acids Res. 34:4495-4505(2006)

PubMed=17555786; DOI=10.1016/j.virol.2007.05.016
Manley K., Gee G.V., Simkevich C.P., Sedivy J.M., Atwood W.J.
Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.
Virology 366:394-404(2007)

PubMed=17881653; DOI=10.1093/hmg/ddm270
Claassen D.A., Lahue R.S.
Expansions of CAG.CTG repeats in immortalized human astrocytes.
Hum. Mol. Genet. 16:3088-3096(2007)

PubMed=24760884; DOI=10.1128/JVI.00696-14
Henriksen S., Tylden G.D., Dumoulin A., Sharma B.N., Hirsch H.H., Rinaldo C.H.
The human fetal glial cell line SVG p12 contains infectious BK polyomavirus.
J. Virol. 88:7556-7568(2014)

PubMed=28973443; DOI=10.1093/nar/gkx650
Keogh N., Chan K.Y., Li G.-M., Lahue R.S.
MutSbeta abundance and Msh3 ATP hydrolysis activity are important drivers of CTG*CAG repeat expansions.
Nucleic Acids Res. 45:10068-10078(2017)

PubMed=30044992; DOI=10.1016/j.celrep.2018.06.100
Coulter M.E., Dorobantu C.M., Lodewijk G.A., Delalande F., Cianferani S., Ganesh V.S., Smith R.S., Lim E.T., Xu C.S., Pang S., Wong E.T., Lidov H.G.W., Calicchio M.L., Yang E., Gonzalez D.M., Schlaeger T.M., Mochida G.H., Hess H., Lee W.-C.A., Lehtinen M.K., Kirchhausen T.L., Haussler D., Jacobs F.M.J., Gaudin R., Walsh C.A.
The ESCRT-III protein CHMP1A mediates secretion of sonic hedgehog on a distinctive subtype of extracellular vesicles.
Cell Rep. 24:973-986.e8(2018)

Cross-references
Cell line collections (Providers) CancerTools; 153563
Ximbio; 153563
Anatomy/cell type resources BTO; BTO:0006555
Encyclopedic resources Wikidata; Q54971010
Gene expression databases GEO; GSM189708
GEO; GSM189709
GEO; GSM189710
GEO; GSM189714
GEO; GSM189715
GEO; GSM189716
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number12