ID   U-251MG sp
AC   CVCL_5G56
SY   U-251 MG sp; U-251 MGsp; U-251SP
DR   BTO; BTO:0005865
DR   cancercelllines; CVCL_5G56
DR   Wikidata; Q54973555
RX   DOI=10.1016/B978-0-12-333530-2.50005-8;
RX   PubMed=1847665;
RX   PubMed=2454731;
RX   PubMed=3675803;
RX   PubMed=6260907;
CC   Population: Caucasian.
CC   Characteristics: Spindle cell variant obtained by differential trypsinization of parent cell line.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0021 ! U-251MG
SX   Male
AG   75Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 15
//
RX   DOI=10.1016/B978-0-12-333530-2.50005-8;
RA   Nister M., Westermark B.;
RT   "Human glioma cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994).
//
RX   PubMed=1847665;
RA   Bongcam-Rudloff E., Nister M., Betsholtz C., Wang J.-L., Stenman G.,
RA   Huebner K., Croce C.M., Westermark B.;
RT   "Human glial fibrillary acidic protein: complementary DNA cloning,
RT   chromosome localization, and messenger RNA expression in human glioma
RT   cell lines of various phenotypes.";
RL   Cancer Res. 51:1553-1560(1991).
//
RX   PubMed=2454731;
RA   Nister M., Libermann T.A., Betsholtz C., Pettersson M.,
RA   Claesson-Welsh L., Heldin C.-H., Schlessinger J., Westermark B.;
RT   "Expression of messenger RNAs for platelet-derived growth factor and
RT   transforming growth factor-alpha and their receptors in human
RT   malignant glioma cell lines.";
RL   Cancer Res. 48:3910-3918(1988).
//
RX   PubMed=3675803;
RA   Bigner S.H., Bjerkvig R., Laerum O.D., Muhlbaier L.H., Bigner D.D.;
RT   "DNA content and chromosomes in permanent cultured cell lines derived
RT   from malignant human gliomas.";
RL   Anal. Quant. Cytol. Histol. 9:435-444(1987).
//
RX   PubMed=6260907; DOI=10.1097/00005072-198105000-00001;
RA   Bigner D.D., Bigner S.H., Ponten J., Westermark B., Mahaley M.S. Jr.,
RA   Ruoslahti E., Herschman H., Eng L.F., Wikstrand C.J.;
RT   "Heterogeneity of genotypic and phenotypic characteristics of fifteen
RT   permanent cell lines derived from human gliomas.";
RL   J. Neuropathol. Exp. Neurol. 40:201-229(1981).
//