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Cellosaurus CCRF-CEM/MTX60-PGA (CVCL_5H86)

[Text version]
Cell line name CCRF-CEM/MTX60-PGA
Synonyms CEM/MTX60PGA
Accession CVCL_5H86
Resource Identification Initiative To cite this cell line use: CCRF-CEM/MTX60-PGA (RRID:CVCL_5H86)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=9369939; DOI=10.1111/j.1349-7006.1997.tb00467.x
Miyachi H., Takemura Y., Kobayashi H., Ando Y.
Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate.
Jpn. J. Cancer Res. 88:900-906(1997)

PubMed=12482398; DOI=10.1006/bcmd.2002.0530
Efferth T., Verdorfer I., Miyachi H., Sauerbrey A., Drexler H.G., Chitambar C.R., Haber M., Gebhart E.
Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.
Blood Cells Mol. Dis. 29:1-13(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5H86
Encyclopedic resources Wikidata; Q54809032
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number16