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Cellosaurus RST2 (CVCL_5I55)

[Text version]
Cell line name RST2
Accession CVCL_5I55
Resource Identification Initiative To cite this cell line use: RST2 (RRID:CVCL_5I55)
Comments Population: African; Kenyan.
Characteristics: Resistant to the various effects of interferon-alpha.
Characteristics: Expresses a STAT2 mRNA with an alternative splice site between exon 19 and 20 that causes STAT2 translation termination at the beginning of the SH2 domain.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0008 (Daudi)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
Publications

PubMed=19687011; DOI=10.1074/jbc.M109.028324
Du Z.-Y., Fan M.-Y., Kim J.-G., Eckerle Mize D.L., Lothstein L., Wei L., Pfeffer L.M.
Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents.
J. Biol. Chem. 284:27808-27815(2009)

Cross-references
Cell line collections (Providers) Kerafast; EH0001
Cell line databases/resources cancercelllines; CVCL_5I55
Encyclopedic resources Wikidata; Q54951344
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number17