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Cellosaurus RST2 (CVCL_5I55)

[Text version]

Cell line name RST2
Accession CVCL_5I55
Resource Identification Initiative To cite this cell line use: RST2 (RRID:CVCL_5I55)
Comments Characteristics: Resistant to the various effects of interferon-alpha.
Characteristics: Expresses a STAT2 mRNA with an alternative splice site between exon 19 and 20 that causes STAT2 translation termination at the beginning of the SH2 domain.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Sequence variations Homozygous for B2M p.Met1Ile (c.3G>C) (from parent cell line).
Homozygous for CTNNB1 p.Ala5_Ala80del (c.14_241del228) (from parent cell line).
TP53 p.Arg213Ter (c.637C>T) (from parent cell line).
Disease Epstein-Barr virus-related Burkitt lymphoma (NCIt: C27694)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0008 (Daudi)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
Web pages https://www.kerafast.com/product/293/stat2-defective-mutant-daudi-cells-rst2

PubMed=19687011; DOI=10.1074/jbc.M109.028324
Du Z., Fan M., Kim J.-G., Eckerle D., Lothstein L., Wei L., Pfeffer L.M.
Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents.
J. Biol. Chem. 284:27808-27815(2009)

Other Wikidata; Q54951344
Entry history
Entry creation14-Dec-2015
Last entry updated24-May-2019
Version number8