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Cellosaurus MCF-7-FLV1000 (CVCL_5I64)

[Text version]

Cell line name MCF-7-FLV1000
Synonyms MCF-7 FLV1000; MCF-7/Flv1000; MCF7-FLV1000; MCF-7FL-1000; MCF-7-FL1000; MCF-7 FL1000; MCF7FL1000; MCF FLV1000
Accession CVCL_5I64
Resource Identification Initiative To cite this cell line use: MCF-7-FLV1000 (RRID:CVCL_5I64)
Comments Selected for resistance to: ChEBI; CHEBI:47344; Alvocidib (Flavopiridol; HMR-1275).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Robey R.W., Medina-Perez W.Y., Nishiyama K., Lahusen T., Miyake K., Litman T., Senderowicz A.M., Ross D.D., Bates S.E.
Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
Clin. Cancer Res. 7:145-152(2001)

Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

Other Wikidata; Q54904332
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number8