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Cellosaurus MCF-7/VP (CVCL_5I65)

[Text version]

Cell line name MCF-7/VP
Synonyms MCF7-VP; MCF7/VP; MCF-7/VP16; MCF7-VP16
Accession CVCL_5I65
Resource Identification Initiative To cite this cell line use: MCF-7/VP (RRID:CVCL_5I65)
Comments Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Schneider E., Horton J.K., Yang C.-H., Nakagawa M., Cowan K.H.
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.
Cancer Res. 54:152-158(1994)

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Chemistry resources ChEMBL-Cells; CHEMBL3307299
ChEMBL-Cells; CHEMBL3307368
ChEMBL-Targets; CHEMBL614128
ChEMBL-Targets; CHEMBL614329
Other Wikidata; Q54904398
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7