ID   MCF-7/VP
AC   CVCL_5I65
SY   MCF7-VP; MCF7/VP; MCF-7 VP-16; MCF-7/VP16; MCF7-VP16
DR   cancercelllines; CVCL_5I65
DR   ChEMBL-Cells; CHEMBL3307299
DR   ChEMBL-Targets; CHEMBL614128
DR   ChEMBL-Targets; CHEMBL614329
DR   PubChem_Cell_line; CVCL_5I65
DR   Wikidata; Q54904398
RX   PubMed=7903202;
RX   PubMed=8562478;
RX   PubMed=11406094;
CC   Population: Caucasian.
CC   Doubling time: 47 hours (PubMed=8562478).
CC   Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 14
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RX   PubMed=7903202;
RA   Schneider E., Horton J.K., Yang C.-H., Nakagawa M., Cowan K.H.;
RT   "Multidrug resistance-associated protein gene overexpression and
RT   reduced drug sensitivity of topoisomerase II in a human breast
RT   carcinoma MCF7 cell line selected for etoposide resistance.";
RL   Cancer Res. 54:152-158(1994).
//
RX   PubMed=8562478;
RA   Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M.,
RA   Gudas J.M., Bates S.E.;
RT   "Normal p53 status and function despite the development of drug
RT   resistance in human breast cancer cells.";
RL   Cell Growth Differ. 6:1395-1403(1995).
//
RX   PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X;
RA   Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T.,
RA   Litman T., Bates S.E.;
RT   "A functional assay for detection of the mitoxantrone resistance
RT   protein, MXR (ABCG2).";
RL   Biochim. Biophys. Acta 1512:171-182(2001).
//