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Cellosaurus TH1 (CVCL_5J51)

[Text version]

Cell line name TH1
Accession CVCL_5J51
Resource Identification Initiative To cite this cell line use: TH1 (RRID:CVCL_5J51)
Comments Characteristics: The transfected hTERT and SV40 Tag genes are flanked by loxP sites. Transient Cre expression in this cell line leads to deletion of the two genes thus leading to a decrease in the rate of cell proliferation and ultimately to cell senescence.
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from sampling site: Kidney; proximal tubule.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5J52 ! TH7
Category Transformed cell line
Publications

PubMed=15208689; DOI=10.1038/sj.onc.1207801
Kowolik C.M., Liang S., Yu Y., Yee J.-K.
Cre-mediated reversible immortalization of human renal proximal tubular epithelial cells.
Oncogene 23:5950-5957(2004)

Patent=US20050136539
Kowolik C.M., Yee J.-K.
Reversible immortalization of human renal proximal tubular epithelial cells.
Patent number US20050136539, 23-Jun-2005

Cross-references
Cell line collections Kerafast; ECH001
Other Wikidata; Q54972283
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7