ID   TH1
AC   CVCL_5J51
DR   Kerafast; ECH001
DR   Wikidata; Q54972283
RX   Patent=US20050136539;
RX   PubMed=15208689;
CC   Group: Patented cell line.
CC   Characteristics: Reversible immortalized. The transfected hTERT and SV40 Tag genes are flanked by loxP sites. Transient Cre expression in this cell line leads to deletion of the two genes thus leading to a decrease in the rate of cell proliferation and ultimately to cell senescence.
CC   Doubling time: 40-48 hours (PubMed=15208689).
CC   Transfected with: HGNC; 11730; TERT.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134.
CC   Cell type: Epithelial cell of proximal tubule; CL=CL_0002306.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5J52 ! TH7
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 14-12-15; Last updated: 29-06-23; Version: 11
//
RX   Patent=US20050136539;
RA   Kowolik C.M., Yee J.-K.;
RT   "Reversible immortalization of human renal proximal tubular epithelial
RT   cells.";
RL   Patent number US20050136539, 23-Jun-2005.
//
RX   PubMed=15208689; DOI=10.1038/sj.onc.1207801;
RA   Kowolik C.M., Liang S., Yu Y., Yee J.-K.;
RT   "Cre-mediated reversible immortalization of human renal proximal
RT   tubular epithelial cells.";
RL   Oncogene 23:5950-5957(2004).
//