Cellosaurus BV-173/E255K (CVCL_5K95)

Cell line name BV-173/E255K
Synonyms BV173/E255K
Accession CVCL_5K95
Resource Identification Initiative To cite this cell line use: BV-173/E255K (RRID:CVCL_5K95)
Comments Selected for resistance to: ChEBI; CHEBI:45783; Imatinib (Gleevec; STI571).
Sequence variation: ABL1 p.Glu255Lys (PubMed=21474579).
Derived from sampling site: Peripheral blood.
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0181 (BV-173)
Sex of cell Male
Category Cancer cell line
Web pages https://www.kerafast.com/product/2471/imatinib-mesylate-im-resistant-all-cell-line-bv173e255k
Publications

PubMed=21474579; DOI=10.1158/1078-0432.CCR-11-0234
Nguyen T., Dai Y., Attkisson E., Kramer L., Jordan N., Nguyen N., Kolluri N., Muschen M., Grant S.
HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.
Clin. Cancer Res. 17:3219-3232(2011)