Cellosaurus logo
expasy logo

Cellosaurus Adult/T315I (CVCL_5K96)

[Text version]
Cell line name Adult/T315I
Accession CVCL_5K96
Resource Identification Initiative To cite this cell line use: Adult/T315I (RRID:CVCL_5K96)
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=21474579).
  • Mutation; HGNC; 76; ABL1; Simple; p.Thr315Ile (c.944C>T) (c.1001C>T); ClinVar=VCV000012624; Zygosity=Unspecified (PubMed=21474579).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=21474579; DOI=10.1158/1078-0432.CCR-11-0234
Nguyen T., Dai Y., Attkisson E., Kramer L., Jordan N., Nguyen N., Kolluri N., Muschen M., Grant S.
HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.
Clin. Cancer Res. 17:3219-3232(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5K96
Encyclopedic resources Wikidata; Q54608870
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number11