ID   MDA-MB-435s-mKate2
AC   CVCL_5T70
DR   cancercelllines; CVCL_5T70
DR   Wikidata; Q54904638
RX   PubMed=25902968;
CC   Problematic cell line: Contaminated. Grand-parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: mKate2, a bright red fluorescent protein derived from eqFP578.
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0622 ! MDA-MB-435S
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 23-02-16; Last updated: 05-10-23; Version: 18
//
RX   PubMed=25902968; DOI=10.1007/s11307-015-0853-5;
RA   Vuletic I., Liu J.-H., Wu H.-L., Ding Y.-C., Lei Y., Li C.-H.,
RA   Zhu D.-H., Ren Q.-S., Sun H.-F., Li J.;
RT   "Establishment of an mKate2-expressing cell line for non-invasive
RT   real-time breast cancer in vivo imaging.";
RL   Mol. Imaging Biol. 17:811-818(2015).
//