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Cellosaurus SK-MEL-103 (CVCL_6069)

[Text version]

Cell line name SK-MEL-103
Synonyms SK-Mel-103; SKMEL-103; SkMel103; SKMEL103
Accession CVCL_6069
Resource Identification Initiative To cite this cell line use: SK-MEL-103 (RRID:CVCL_6069)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations NRAS p.Gln61Arg (c.182A>G) (PubMed=21725359; PubMed=24576830).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
Publications

PubMed=7747814
Gruis N.A., Weaver-Feldhaus J., Liu Q., Frye C., Eeles R., Orlow I., Lacombe L., Ponce-Castaneda V., Lianes P., Latres E., Skolnick M., Cordon-Cardo C., Kamb A.
Genetic evidence in melanoma and bladder cancers that p16 and p53 function in separate pathways of tumor suppression.
Am. J. Pathol. 146:1199-1206(1995)

PubMed=17308088; DOI=10.1158/0008-5472.CAN-06-3311
Shields J.M., Thomas N.E., Cregger M., Berger A.J., Leslie M., Torrice C., Hao H., Penland S., Arbiser J.L., Scott G., Zhou T., Bar-Eli M., Bear J.E., Der C.J., Kaufmann W.K., Rimm D.L., Sharpless N.E.
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma.
Cancer Res. 67:1502-1512(2007)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958
Rose A.E., Poliseno L., Wang J., Clark M., Pearlman A., Wang G., Vega Y Saenz de Miera E.C., Medicherla R., Christos P.J., Shapiro R., Pavlick A., Darvishian F., Zavadil J., Polsky D., Hernando E., Ostrer H., Osman I.
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

PubMed=21725359; DOI=10.1038/onc.2011.250
Xing F., Persaud Y., Pratilas C.A., Taylor B.S., Janakiraman M., She Q.-B., Gallardo H., Liu C., Merghoub T., Hefter B., Dolgalev I., Viale A.J., Heguy A., de Stanchina E., Cobrinik D., Bollag G., Wolchok J.D., Houghton A.N., Solit D.B.
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625
Nissan M.H., Pratilas C.A., Jones A.M., Ramirez R., Won H., Liu C., Tiwari S., Kong L., Hanrahan A.J., Yao Z., Merghoub T., Ribas A., Chapman P.B., Yaeger R., Taylor B.S., Schultz N., Berger M.F., Rosen N., Solit D.B.
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line databases/resources Lonza; 1337
Gene expression databases GEO; GSM555127
GEO; GSM555180
GEO; GSM784512
GEO; GSM3039513
Other Wikidata; Q54953761
Polymorphism and mutation databases Cosmic; 685207
Cosmic; 1054850
Cosmic; 1122258
Cosmic; 1507613
Cosmic; 1669161
Entry history
Entry creation04-Apr-2012
Last entry updated25-Feb-2019
Version number15