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Cellosaurus RT112/D21 (CVCL_6215)

[Text version]
Cell line name RT112/D21
Synonyms RT-112-D21
Accession CVCL_6215
Resource Identification Initiative To cite this cell line use: RT112/D21 (RRID:CVCL_6215)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Gene fusion; HGNC; 3690; FGFR3 + HGNC; 11524; TACC3; Name(s)=FGFR3-TACC3 (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser183Ter (c.548C>G); ClinVar=VCV000634701; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1670 (RT-112)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CLS

Markers:
AmelogeninX
CSF1PO10,11
D3S135815
D5S81810,13
D7S82011,12
D8S117913,15
D13S31713,14
D16S53911,13
D18S5115
D21S1127,30
FGA23
Penta D10,11
Penta E12,16
TH017
TPOX8,11
vWA14,17

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Publications

PubMed=7740654; DOI=10.1007/BF00296874
Seemann O., Muscheck M., Siegsmund M.J., Pilch H., Nebe C.T., Rassweiler J., Alken P.
Establishment and characterization of a multidrug-resistant human bladder carcinoma cell line RT112/D21.
Urol. Res. 22:353-360(1995)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cross-references
Cell line collections (Providers) CLS; 300325
Cell line databases/resources cancercelllines; CVCL_6215
Encyclopedic resources Wikidata; Q54951357
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number20