Cellosaurus cell line A375-P (CVCL_6233)

• Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  

PubMed=2731157; DOI=10.1016/0304-3835(89)90148-1
Yohem K.H., Seftor E.A., Meyskens F.L. Jr., Hendrix M.J.C.
Cloning efficiency of human melanoma cells is modulated after invasion through a reconstituted basement membrane.
Cancer Lett. 45:135-143(1989)

PubMed=1671030; DOI=10.1002/ijc.2910470211
Welch D.R., Bisi J.E., Miller B.E., Conaway D.H., Seftor E.A., Yohem K.H., Gilmore L.B., Seftor R.E.B., Nakajima M., Hendrix M.J.C.
Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line.
Int. J. Cancer 47:227-237(1991)

PubMed=22323893; DOI=10.3109/10623329609024685
Sriramarao P., Bourdon M.A.
Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression.
Endothelium 4:85-97(1996)

PubMed=10952316; DOI=10.1038/35020106
Clark E.A., Golub T.R., Lander E.S., Hynes R.O.
Genomic analysis of metastasis reveals an essential role for RhoC.
Nature 406:532-535(2000)