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Cellosaurus A375-P (CVCL_6233)

[Text version]

Cell line name A375-P
Synonyms A-375P; A375P; A375p
Accession CVCL_6233
Resource Identification Initiative To cite this cell line use: A375-P (RRID:CVCL_6233)
Sequence variations Homozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Homozygous for CDKN2A p.Glu61Ter (c.181G>T) (p.Gly75Val; c.224G>T) and p.Glu69Ter (c.205G>T) (p.Gly83Val; c.248G>T) (from parent cell line).
TERT c.250C>T (-146C>T); in promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Children:
CVCL_RN37 (A375P-5)CVCL_5F66 (A375P-beta6/puro)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11,12
D5S81812
D7S8209
D13S31711,14
D16S5399
TH018
TPOX8,10
vWA16,17

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Publications

PubMed=2731157; DOI=10.1016/0304-3835(89)90148-1
Yohem K.H., Seftor E.A., Meyskens F.L. Jr., Hendrix M.J.C.
Cloning efficiency of human melanoma cells is modulated after invasion through a reconstituted basement membrane.
Cancer Lett. 45:135-143(1989)

PubMed=1671030; DOI=10.1002/ijc.2910470211
Welch D.R., Bisi J.E., Miller B.E., Conaway D.H., Seftor E.A., Yohem K.H., Gilmore L.B., Seftor R.E.B., Nakajima M., Hendrix M.J.C.
Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line.
Int. J. Cancer 47:227-237(1991)

PubMed=22323893; DOI=10.3109/10623329609024685
Sriramarao P., Bourdon M.A.
Melanoma cell invasive and metastatic potential correlates with endothelial cell reorganization and tenascin expression.
Endothelium 4:85-97(1996)

Cross-references
Cell line collections ATCC; CRL-3224
KCLB; 80003
Ontologies BTO; BTO:0003984
Other Wikidata; Q54606807
Polymorphism and mutation databases Cosmic; 932714
Cosmic; 1045406
Cosmic; 1067223
Cosmic; 1238110
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number14