ID   A375-P
AC   CVCL_6233
SY   A-375P; A375P; A375p
DR   BTO; BTO:0003984
DR   ATCC; CRL-3224
DR   cancercelllines; CVCL_6233
DR   ChEMBL-Cells; CHEMBL4879545
DR   Cosmic; 932714
DR   Cosmic; 1045406
DR   Cosmic; 1067223
DR   Cosmic; 1238110
DR   KCLB; 80003
DR   PRIDE; PXD005277
DR   Wikidata; Q54606807
RX   PubMed=1671030;
RX   PubMed=2731157;
RX   PubMed=10952316;
RX   PubMed=22323893;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
ST   Source(s): ATCC
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,14
ST   D16S539: 9
ST   D5S818: 12
ST   D7S820: 9
ST   TH01: 8
ST   TPOX: 8,10
ST   vWA: 16,17
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
//
RX   PubMed=1671030; DOI=10.1002/ijc.2910470211;
RA   Welch D.R., Bisi J.E., Miller B.E., Conaway D.H., Seftor E.A.,
RA   Yohem K.H., Gilmore L.B., Seftor R.E.B., Nakajima M., Hendrix M.J.C.;
RT   "Characterization of a highly invasive and spontaneously metastatic
RT   human malignant melanoma cell line.";
RL   Int. J. Cancer 47:227-237(1991).
//
RX   PubMed=2731157; DOI=10.1016/0304-3835(89)90148-1;
RA   Yohem K.H., Seftor E.A., Meyskens F.L. Jr., Hendrix M.J.C.;
RT   "Cloning efficiency of human melanoma cells is modulated after
RT   invasion through a reconstituted basement membrane.";
RL   Cancer Lett. 45:135-143(1989).
//
RX   PubMed=10952316; DOI=10.1038/35020106;
RA   Clark E.A., Golub T.R., Lander E.S., Hynes R.O.;
RT   "Genomic analysis of metastasis reveals an essential role for RhoC.";
RL   Nature 406:532-535(2000).
//
RX   PubMed=22323893; DOI=10.3109/10623329609024685;
RA   Sriramarao P., Bourdon M.A.;
RT   "Melanoma cell invasive and metastatic potential correlates with
RT   endothelial cell reorganization and tenascin expression.";
RL   Endothelium 4:85-97(1996).
//