ID   661W
AC   CVCL_6240
SY   661w; 661 W
DR   BTO; BTO:0001554
DR   ChEMBL-Cells; CHEMBL4483169
DR   ChEMBL-Targets; CHEMBL4483223
DR   GEO; GSE119190
DR   Lonza; 336
DR   PubChem_Cell_line; CVCL_6240
DR   Wikidata; Q54604409
RX   PubMed=11243878;
RX   PubMed=12407171;
RX   PubMed=14985288;
RX   PubMed=18188958;
RX   PubMed=23975727;
RX   PubMed=26854824;
RX   PubMed=29203899;
RX   PubMed=31024622;
RX   PubMed=31819341;
CC   Doubling time: ~24 hours (PubMed=12407171).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Proteome analysis by 2D-DE/MS.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Eye, retina; UBERON=UBERON_0000966.
CC   Cell type: Retinal cone cell; CL=CL_0000573.
CC   Breed/subspecies: C57BL/6N transgenic.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Male
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 14
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RX   PubMed=11243878; DOI=10.1006/bbrc.2001.4501;
RA   Crawford M.J., Krishnamoorthy R.R., Rudick V.L., Collier R.J.,
RA   Kapin M., Aggarwal B.B., Al-Ubaidi M.R., Agarwal N.;
RT   "Bcl-2 overexpression protects photooxidative stress-induced apoptosis
RT   of photoreceptor cells via NF-kappaB preservation.";
RL   Biochem. Biophys. Res. Commun. 281:1304-1312(2001).
//
RX   PubMed=12407171;
RA   Tuohy G., Millington-Ward S., Kenna P.F., Humphries P., Farrar G.J.;
RT   "Sensitivity of photoreceptor-derived cell line (661W) to baculoviral
RT   p35, Z-VAD.FMK, and Fas-associated death domain.";
RL   Invest. Ophthalmol. Vis. Sci. 43:3583-3589(2002).
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RX   PubMed=14985288; DOI=10.1167/iovs.03-1114;
RA   Tan E., Ding X.-Q., Saadi A., Agarwal N., Naash M.I., Al-Ubaidi M.R.;
RT   "Expression of cone-photoreceptor-specific antigens in a cell line
RT   derived from retinal tumors in transgenic mice.";
RL   Invest. Ophthalmol. Vis. Sci. 45:764-768(2004).
//
RX   PubMed=18188958; DOI=10.1007/978-0-387-74904-4_35;
RA   Al-Ubaidi M.R., Matsumoto H., Kurono S., Singh A.;
RT   "Proteomics profiling of the cone photoreceptor cell line, 661W.";
RL   Adv. Exp. Med. Biol. 613:301-311(2008).
//
RX   PubMed=23975727; DOI=10.1167/iovs.13-12085;
RA   Krishnamoorthy R.R., Clark A.F., Daudt D., Vishwanatha J.K., Yorio T.;
RT   "A forensic path to RGC-5 cell line identification: lessons learned.";
RL   Invest. Ophthalmol. Vis. Sci. 54:5712-5719(2013).
//
RX   PubMed=26854824; DOI=10.1016/j.exer.2016.01.016;
RA   Pfeffer B.A., Xu L.-B., Porter N.A., Rao S.R., Fliesler S.J.;
RT   "Differential cytotoxic effects of 7-dehydrocholesterol-derived
RT   oxysterols on cultured retina-derived cells: dependence on sterol
RT   structure, cell type, and density.";
RL   Exp. Eye Res. 145:297-316(2016).
//
RX   PubMed=29203899; DOI=10.1038/s41598-017-17241-0;
RA   Sayyad Z., Sirohi K., Radha V., Swarup G.;
RT   "661W is a retinal ganglion precursor-like cell line in which
RT   glaucoma-associated optineurin mutants induce cell death
RT   selectively.";
RL   Sci. Rep. 7:16855-16855(2017).
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RX   PubMed=31024622; DOI=10.3389/fgene.2019.00308;
RA   Wheway G., Nazlamova L., Turner D., Cross S.;
RT   "661W photoreceptor cell line as a cell model for studying retinal
RT   ciliopathies.";
RL   Front. Genet. 10:308.1-308.14(2019).
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RX   PubMed=31819341;
RA   Sanchez-Bretano A., Suen T.-C., Baba K., DeBruyne J.P., Tosini G.;
RT   "Melatonin receptor heterodimerization in a photoreceptor-like cell
RT   line endogenously expressing melatonin receptors.";
RL   Mol. Vis. 25:791-799(2019).
//