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Cellosaurus CEM A3.01 (CVCL_6244)

[Text version]

Cell line name CEM A3.01
Synonyms A3.01
Accession CVCL_6244
Resource Identification Initiative To cite this cell line use: CEM A3.01 (RRID:CVCL_6244)
Comments Population: Caucasian.
Characteristics: CD4+/CXCR4+.
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_W647 (12D7 )CVCL_3484 (8E5 )CVCL_S540 (A3R5.7 )
CVCL_0138 (ACH-2 )CVCL_X698 (CEM A2.01 )
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=2989831; DOI=10.1073/pnas.82.13.4539
Folks T.M., Benn S., Rabson A., Theodore T., Hoggan M.D., Martin M., Lightfoote M., Sell K.
Characterization of a continuous T-cell line susceptible to the cytopathic effects of the acquired immunodeficiency syndrome (AIDS)-associated retrovirus.
Proc. Natl. Acad. Sci. U.S.A. 82:4539-4543(1985)

PubMed=24312168; DOI=10.1371/journal.pone.0077756
McLinden R.J., Labranche C.C., Chenine A.-L., Polonis V.R., Eller M.A., Wieczorek L., Ochsenbauer-Jambor C., Kappes J.C., Perfetto S., Montefiori D.C., Michael N.L., Kim J.H.
Detection of HIV-1 neutralizing antibodies in a human CD4(+)/CXCR4(+)/CCR5(+) T-lymphoblastoid cell assay system.
PLoS ONE 8:E77756-E77756(2013)

Cross-references
Cell line collections HIVReagentProgram; ARP-166
Cell line databases/resources Lonza; 362
Encyclopedic resources Wikidata; Q54606728
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number18