ID   CEM A3.01
AC   CVCL_6244
SY   A3.01
DR   cancercelllines; CVCL_6244
DR   HIVReagentProgram; ARP-166
DR   Lonza; 362
DR   Wikidata; Q54606728
RX   PubMed=2989831;
RX   PubMed=24312168;
CC   Population: Caucasian.
CC   Characteristics: CD4+/CXCR4+.
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=2989831; DOI=10.1073/pnas.82.13.4539;
RA   Folks T.M., Benn S., Rabson A., Theodore T., Hoggan M.D., Martin M.,
RA   Lightfoote M., Sell K.;
RT   "Characterization of a continuous T-cell line susceptible to the
RT   cytopathic effects of the acquired immunodeficiency syndrome
RT   (AIDS)-associated retrovirus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:4539-4543(1985).
//
RX   PubMed=24312168; DOI=10.1371/journal.pone.0077756;
RA   McLinden R.J., LaBranche C.C., Chenine A.-L., Polonis V.R., Eller M.A.,
RA   Wieczorek L., Ochsenbauer-Jambor C., Kappes J.C., Perfetto S.,
RA   Montefiori D.C., Michael N.L., Kim J.H.;
RT   "Detection of HIV-1 neutralizing antibodies in a human
RT   CD4(+)/CXCR4(+)/CCR5(+) T-lymphoblastoid cell assay system.";
RL   PLoS ONE 8:E77756-E77756(2013).
//