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Cellosaurus Akata 2A8 (CVCL_6247)

Cell line name Akata 2A8
Synonyms 2A8
Accession CVCL_6247
Resource Identification Initiative To cite this cell line use: Akata 2A8 (RRID:CVCL_6247)
Comments Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Virology: EBV-negative. Treated with hydroxyurea which completely eliminated EBV episomes.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Protein expression by reverse-phase protein arrays.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); ClinVar=VCV000825904; Zygosity=Unspecified (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0148 (Akata)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=9593003; DOI=10.1086/515290
Chodosh J., Holder V.P., Gan Y.-J., Belgaumi A., Sample J.T., Sixbey J.W.
Eradication of latent Epstein-Barr virus by hydroxyurea alters the growth-transformed cell phenotype.
J. Infect. Dis. 177:1194-1201(1998)

PubMed=10022853; DOI=10.1128/mcb.19.3.1651
Ruf I.K., Rhyne P.W., Yang H., Borza C.M., Hutt-Fletcher L.M., Cleveland J.L., Sample J.T.
Epstein-Barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma.
Mol. Cell. Biol. 19:1651-1660(1999)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources Lonza; 137
Encyclopedic resources Wikidata; Q54749082
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number17