| Cell line name |
BHP 17-10 |
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| Synonyms |
BHP17-10; BHP-17 |
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| Accession |
CVCL_6281 |
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| Resource Identification Initiative |
To cite this cell line use: BHP 17-10 (RRID:CVCL_6281) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=18713817; PubMed=20143388). Originally thought to originate from a thyroid gland papillary carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00181.
Population: Caucasian.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072. |
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| Sequence variations |
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Amelanotic melanoma (NCIt: C3802) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1395 (M14) |
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| Sex of cell |
Male |
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| Age at sampling |
33Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): PubMed=18713817
Markers:
Run an STR similarity search on this cell line |
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| Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx |
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| Publications | PubMed=8675585; DOI=10.1210/jcem.81.7.8675585
Ohta K., Pang X.-P., Berg L., Hershman J.M.
Antitumor actions of cytokines on new human papillary thyroid carcinoma cell lines.
J. Clin. Endocrinol. Metab. 81:2607-2612(1996) PubMed=9253346; DOI=10.1210/jcem.82.8.4136
Ohta K., Pang X.-P., Berg L., Hershman J.M.
Growth inhibition of new human thyroid carcinoma cell lines by activation of adenylate cyclase through the beta-adrenergic receptor.
J. Clin. Endocrinol. Metab. 82:2633-2638(1997) PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008) PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_6281
|
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| Biological sample resources |
BioSample; SAMN03151828
|
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| Encyclopedic resources |
Wikidata; Q54796494
|
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| Polymorphism and mutation databases |
Cosmic; 1005451
Cosmic; 1094769
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 25 |
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