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Cellosaurus HTh74 (CVCL_6288)

[Text version]
Cell line name HTh74
Synonyms Hth74; HTH74; HTh 74; HTh-74; Uhth-74; U-hth74
Accession CVCL_6288
Resource Identification Initiative To cite this cell line use: HTh74 (RRID:CVCL_6288)
Comments Characteristics: Established from a tumor implanted into a nude mice (PubMed=1655394).
Omics: Transcriptome analysis by microarray.
Misspelling: Hth47; Cosmic=889490.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; 7765; NF1; Simple; p.Leu732fs (c.2195_2202delTGCCCAAC); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=30737244).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_AT82 (HTh74 clone 7)
Sex of cell Female
Age at sampling 73Y
Category Cancer cell line
STR profile Source(s): PubMed=17465858; PubMed=18713817; PubMed=25365311; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,12 (PubMed=30737244)
11,12 (PubMed=25365311)
D3S135815
D5S81811,12
D7S8208,9 (PubMed=17465858; PubMed=18713817; PubMed=30737244)
9 (PubMed=25365311)
D8S117913,15 (PubMed=17465858; PubMed=30737244)
13,15,16 (PubMed=18713817)
D13S31712,13
D16S5399 (PubMed=25365311)
11 (PubMed=30737244)
D18S5114
D21S1131,32 (PubMed=17465858; PubMed=30737244)
32 (PubMed=18713817)
FGA25
TH018 (PubMed=25365311)
8,9 (PubMed=30737244)
TPOX8,10 (PubMed=25365311)
11 (PubMed=30737244)
vWA16,17 (PubMed=25365311)
17,19 (PubMed=17465858; PubMed=18713817; PubMed=30737244)

Run an STR similarity search on this cell line
Publications

PubMed=1655394; DOI=10.1210/endo-129-4-2187
Heldin N.-E., Cvejic D., Smeds S., Westermark B.
Coexpression of functionally active receptors for thyrotropin and platelet-derived growth factor in human thyroid carcinoma cells.
Endocrinology 129:2187-2193(1991)

PubMed=1726925
Gerber H., Peter H.-J., Asmis L., Studer H.
Thyroid cell lines in research on goitrogenesis.
Thyroidology 3:115-118(1991)

PubMed=14522906
Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=17465858; DOI=10.1089/thy.2006.0246
Lee J.-J., Foukakis T., Hashemi J., Grimelius L., Heldin N.-E., Wallin G., Rudduck C., Lui W.-O., Hoog A., Larsson C.
Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models.
Thyroid 17:289-301(2007)

PubMed=17725429; DOI=10.1089/thy.2007.0097
Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.
Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
Thyroid 17:707-715(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=19087340; DOI=10.1186/1471-2407-8-371
Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.
Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
BMC Cancer 8:371.1-371.11(2008)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25365311; DOI=10.1210/jc.2014-2359
Garg M., Okamoto R., Nagata Y., Kanojia D., Venkatesan S., Anand M.T., Braunstein G.D., Said J.W., Doan N.B., Ho Q., Akagi T., Gery S., Liu L.-Z., Tan K.T., Chang W.J., Yang H., Ogawa S., Koeffler H.P.
Establishment and characterization of novel human primary and metastatic anaplastic thyroid cancer cell lines and their genomic evolution over a year as a primagraft.
J. Clin. Endocrinol. Metab. 100:725-735(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Anatomy/cell type resources BTO; BTO:0005147
Encyclopedic resources Wikidata; Q54896656
Polymorphism and mutation databases Cosmic; 889490
Cosmic; 1068623
Cosmic; 1084284
Cosmic; 1132594
Cosmic; 1152119
Cosmic; 1239982
Cosmic; 1280050
Cosmic; 1507377
Cosmic; 1533554
Cosmic; 1536130
Cosmic; 1889009
Cosmic; 2036690
Cosmic; 2050368
Cosmic; 2054102
Cosmic; 2319855
Cosmic; 2791086
IARC_TP53; 21622
IARC_TP53; 25014
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number25