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Cellosaurus TTA-1 (CVCL_6297)

[Text version]
Cell line name TTA-1
Synonyms TTA1; TTA-I
Accession CVCL_6297
Resource Identification Initiative To cite this cell line use: TTA-1 (RRID:CVCL_6297)
Comments Group: Patented cell line.
Registration: International Depositary Authority, Japanese National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology; FERM BP-7523.
Population: Japanese.
Doubling time: 28.8 hours (PubMed=8121182).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; 7883; NOTCH3; Simple; p.Gly289fs (c.866delG); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg158Leu (c.473G>T); ClinVar=VCV000528248; Zygosity=Homozygous (PubMed=30737244).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): PubMed=18713817; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,11
D3S135815
D5S81812,13
D7S82011,12
D8S117913,15
D13S31712
D16S5399,10
D18S5115
D21S1130
FGA23
TH016
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8121182; DOI=10.1002/jso.2930550209
Yoshida A., Asaga T., Masuzawa C., Kawahara S., Yanoma S., Harada M., Okamoto T.
Production of cytokines by thyroid carcinoma cell lines.
J. Surg. Oncol. 55:104-107(1994)

PubMed=8176927; DOI=10.1002/jso.2930550308
Yoshida A., Asaga T., Masuzawa C., Kawahara S.
Alteration of tumorigenicity in undifferentiated thyroid carcinoma cells by introduction of normal chromosome 11.
J. Surg. Oncol. 55:170-174(1994)

PubMed=9177455; DOI=10.1016/S0304-3835(97)04742-3
Satake S., Sugawara I., Watanabe M., Takami H.
Lack of a point mutation of human DNA topoisomerase II in multidrug-resistant anaplastic thyroid carcinoma cell lines.
Cancer Lett. 116:33-39(1997)

PubMed=15613457; DOI=10.1677/erc.1.00818
Onda M., Emi M., Yoshida A., Miyamoto S., Akaishi J., Asaka S., Mizutani K., Shimizu K., Nagahama M., Ito K., Tanaka T., Tsunoda T.
Comprehensive gene expression profiling of anaplastic thyroid cancers with cDNA microarray of 25 344 genes.
Endocr. Relat. Cancer 11:843-854(2004)

PubMed=16924234; DOI=10.1038/sj.onc.1209899
Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.
Oncogene 26:1178-1187(2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

Patent=US8029793
Yoshida A., Yanoma S., Hirose F.
Methods for inhibiting cell proliferation.
Patent number US8029793, 04-Oct-2011

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) CLS; 305138
RCB; RCB5467
Cell line databases/resources cancercelllines; CVCL_6297
CCRID; 3101HUMSCSP554
CGH-DB; 46-1
Anatomy/cell type resources BTO; BTO:0004965
Encyclopedic resources Wikidata; Q54973227
Polymorphism and mutation databases Cosmic; 1152125
Cosmic; 1239984
Cosmic; 2054119
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22