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Cellosaurus 1A6 (CVCL_6344)

Cell line name 1A6
Synonyms 5637 subclone 1A6
Accession CVCL_6344
Resource Identification Initiative To cite this cell line use: 1A6 (RRID:CVCL_6344)
Comments Part of: BLA-40 bladder carcinoma cell line panel.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for MAPK1 p.Arg79Lys (c.236G>A) (from parent cell line).
Homozygous for RB1 p.Tyr325Ter (c.975T>A) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
TP53 p.Arg280Thr (c.839G>C) (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0126 (5637)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): ATCC


Gabrilove J.L., Mertelsmann R., Moore M.A.S., Platzer E., Welte K.
Human pluripotent hematopoietic colony stimulating factor and cell line producing same.
Patent number US6114166, 05-Sep-2000

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24018021; DOI=10.1016/j.eururo.2013.08.052
Allory Y., Beukers W., Sagrera A., Flandez M., Marques M., Marquez M., van der Keur K.A., Dyrskjot L., Lurkin I., Vermeij M., Carrato A., Lloreta J., Lorente J.A., Carrillo-de-Santa-Pau E., Masius R.G., Kogevinas M., Steyerberg E.W., van Tilborg A.A.G., Abas C., Orntoft T.F., Zuiverloon T.C.M., Malats N., Zwarthoff E.C., Real F.X.
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
Eur. Urol. 65:360-366(2014)

PubMed=29732388; DOI=10.3233/BLC-180167
Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
Bladder Cancer 4:169-183(2018)

Cell line collections ATCC; CRL-2742 - Discontinued
Cell line databases/resources LINCS_LDP; LCL-1703
Ontologies CLO; CLO_0001149
Gene expression databases GEO; GSM136246
GEO; GSM827286
GEO; GSM1374374
Other Wikidata; Q54582656
Polymorphism and mutation databases Cosmic; 2037945