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Cellosaurus J.gamma1 (CVCL_6410)

[Text version]

Cell line name

J.gamma1

Synonyms

Jgamma1; Jurkat Gamma1

Accession

CVCL_6410

Resource Identification Initiative

To cite this cell line use: J.gamma1 (RRID:CVCL_6410)

Comments

Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Omics: Deep phosphoproteome analysis.
Omics: SNP array analysis.
Derived from sampling site: Peripheral blood.

Sequence variations

Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (from parent cell line).
Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (from parent cell line).
Heterozygous for INPP5D c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line).

Disease

Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0367 (Jurkat E6.1)
Children:

CVCL_6411 (J.gamma1.WT)

Sex of cell

Male

Age at sampling

14Y

Category

Cancer cell line

STR profile

Source(s): ATCC

Markers:

Amelogenin	X
CSF1PO	11,12
D5S818	9
D7S820	8,12
D13S317	8,12
D16S539	11
TH01	6,9.3
TPOX	8,10
vWA	18,19

Publications

PubMed=11094067; DOI=10.1128/MCB.20.24.9149-9161.2000
Irvin B.J., Williams B.L., Nilson A.E., Maynor H.O., Abraham R.T.
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Mol. Cell. Biol. 20:9149-9161(2000)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=26546556; DOI=10.1016/j.jprot.2015.10.029
Nguyen T.D., Carrascal M., Vidal-Cortes O., Gallardo O., Casas V., Gay M., Phan V.C., Abian J.
The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies.
J. Proteomics 131:190-198(2016)

Cross-references

Cell line collections

ATCC; CRL-2678

Cell line databases/resources

LINCS_LDP; LCL-2038

Ontologies

CLO; CLO_0006985

Biological sample resources

BioSample; SAMN03471763

Gene expression databases

GEO; GSM827148

Other